在现实生活中，每25个人中，就有1个人注定比别人寿命短，这被视为短命基因决定的。携带短命基因的人中位生存期比没有携带该基因的人短，10%的携带者在69岁前死亡，而10%的非携带者在73岁前死亡。而且，某些基因让人寿命更短。如乳腺癌易感基因2（BRCA2），是一种致病性突变基因，容易引起乳腺癌、卵巢癌和胰腺癌，可使人寿命缩短约7年。
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